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Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system attacks the body’s own tissues, causing widespread inflammation and damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Asian SLE patients suffer from more severe disease and damage compared to patients in western countries.
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More than half of patients with treatment-refractory HER2-positive non-small cell lung cancer (NSCLC) responded to an anti-HER2 antibody-drug conjugate, data from a preliminary trial showed. Fifty of 91 patients responded to trastuzumab deruxtecan (T-DXd) and another 34 patients had stable disease, resulting in a disease control rate exceeding 90%. Responses were durable in many cases,
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Adjuvant pembrolizumab (Keytruda) following complete melanoma resection could soon move to an earlier stage in the management of high-risk disease, suggest results from KEYNOTE 716. However, the results raise many questions, says an expert invited to discuss the new data. Adjuvant pembrolizumab is already approved in the USA for use in patients with melanoma with
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In this article PFE Top infectious disease expert Dr. Anthony Fauci responds to accusations by Sen. Rand Paul (R-KY) as he testifies before the Senate Health, Education, Labor, and Pensions Committee on Capitol hill in Washington, D.C., July 20, 2021. J. Scott Applewhite | Pool | Reuters Dr. Anthony Fauci defended the Food and Drug
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Scientists at St. Jude Children’s Research Hospital have revealed how the tumor suppressor gene PTEN plays a more important role in pediatric rhabdomyosarcoma than was previously appreciated. The research highlights a possible new treatment approach.The study appears today in Nature Communications. In this study, researchers showed that decreased expression of PTEN makes tumors more aggressive.
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Over the course of the pandemic, researchers nationwide noticed differences in COVID-19 disease between children and adults. While risk factors for hospitalization and poor outcomes are well documented in adults, less is known about the clinical factors associated with COVID disease severity in children. In an effort to aid mitigation strategies for children who are
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As we grow older, our curiosity can fade. Yet research shows that it remains essential to our wellbeing. Here, we explore how to reignite that inquisitive spark As children, we’re full of questions. Why do ladybirds have spots? How do planes stay in the air? Who invented sherbet? But, as we age, that willingness to
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Adding pembrolizumab (Keytruda) to chemotherapy with or without bevacizumab (Avastin) significantly slowed progression of metastatic cervical cancer and improved overall survival (OS), investigators in a randomized trial concluded. Median progression-free survival (PFS) improved from 8.2 months with chemotherapy plus or minus bevacizumab (Avastin) to 10.4 months with the addition of the PD-1 inhibitor. Comparison of
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The visual disorder amblyopia, also known as “lazy eye,” can be impossible to treat once children reach adolescence. Now, a new Israel study links cases in older teenagers to higher rates of poverty, below-average cognitive scores, immigrant status, and obesity.   The research suggests that poorer children need more visual screening, especially in the United States
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A paper published in the journal Psychological Medicine confirms the existence of neurobiological alterations in early stages of life in minors exposed to maltreatment. The study’s first author is the researcher Laia Marqués-Feixa, from the Faculty of Biology, the Institute of Biomedicine of the University of Barcelona (IBUB) and the CIBER Mental Health (CIBERSAM), and
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Epigenetic aging — derived from the molecular mechanisms governing gene regulation — could serve as a promising biomarker for measuring long-term cardiovascular health and disease risk, according to a Northwestern Medicine study published in the journal Circulation Research. Epigenetic aging represents a novel measure of biological age — or how old the body is physiologically,
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Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer. The activation of checkpoint proteins on the surfaces of immune cells helps regulate the immune response by
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Kirsty Gallagher joined Happiful at Wellbeing by the Lakes Festival to talk about the moon, the autumn equinox and why now is the time to follow your dreams… At the beginning of September, Moon Mentor Kirsty Gallagher joinedHappiful on the Riverside Stage at Wellbeing by the Lakes Festival to share her love of lunar living
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TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center in El Paso, look at the top medical stories of the week. This week’s topics include screening for chlamydia and gonorrhea, whether
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Details of what works, and what doesn’t, in triple-negative breast cancer (TNBC) come from long-term follow-up of the phase 3 randomized BrighTNess trial. The initial improvement that was seen in pathologic complete response (pCR) rates with the addition of carboplatin to paclitaxel and standard neoadjuvant chemotherapy translated into improved event-free survival (EFS) rates in patients
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While many parents and caregivers involved in the child welfare system suffered trauma as children, new research suggests that those with substance misuse issues as adults may have had particularly difficult childhoods. The study found that scores assessing childhood trauma exposure among adults with substance misuse issues were 24% higher than previous estimates for other
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Eighteen months into the covid-19 pandemic, with the delta variant fueling a massive resurgence of disease, many hospitals are hitting a heartbreaking new low. They’re now losing babies to the coronavirus. The first reported covid-related death of a newborn occurred in Orange County, Florida, and an infant has died in Mississippi. Merced County in California
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Researchers worldwide hypothesized that the development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could help to reduce transmission and help to lower the mortality rate. The vaccines developed against coronavirus disease 2019 (COVID-19) had to undergo several clinical trials before they could be considered safe for human use. Patients of various age
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Dr Louise Newson is a leading light in the world of menopause education, policy, and support. Believing it’s never too early to be perimenopause savvy, she’s sharing practical information to help everyone have a better experience No matter what your age or gender, chances are you’ve heard about the menopause. You may have noticed a
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Each year since 2018, doctors around the country recognize National Physician Suicide Awareness Day on September 17. One of the co-founders of this awareness campaign, Loice Swisher, MD, of Drexel University College of Medicine in Philadelphia, shared her own experience of suicidal thoughts after her daughter was left “neurologically devastated” following surgery on a malignant
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New evidence suggesting that the benefit of ticagrelor outweighs the risk when added to aspirin for 30 days after a mild-to-moderate ischemic stroke or high-risk transient ischemic attack (TIA) has been reported from a secondary analysis of the THALES trial. The new analysis was presented at the recent European Stroke Organisation Conference (ESOC) and published
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California Governor Gavin Newsom speaks to members of the media after meeting students at Melrose Leadership Academy during a school visit in Oakland, California on Wednesday, Sept. 15, 2021. Stephen Lam | San Francisco Chronicle | Hearst Newspapers via Getty Images California Gov. Gavin Newsom has called his decisive victory in this week’s recall election
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