Clinical Trials & Research

Strong, collaborative relationships with principal investigators are a key factor of longevity in clinical research coordinator positions — an essential, but increasingly transient job in executing treatment-advancing clinical trials, Vanderbilt University Medical Center researchers found. Danielle Buchanan, BS, clinical translational research coordinator III in the Department of Neurology, and Daniel Claassen, MD, MS, chief of

The global population is aging, and so are their eyes. In fact, the number of people with vision impairment and blindness is expected to more than double over the next 30 years. A meta-analysis in The Lancet Global Health, consisting of 48,000 people from 17 studies, found that those with more severe vision impairment had

Being able to make blind people see again sounds like the stuff of miracles or even science fiction. And it has always been one of the biggest challenges for scientists. Diego Ghezzi, who holds the Medtronic Chair in Neuroengineering (LNE) at EPFL’s School of Engineering, has made this issue a research focus. Since 2015, he

GAITHERSBURG, Md., February 25, 2021 — Novavax, Inc. (Nasdaq: NVAX), a biotechnology company developing next-generation vaccines for serious infectious diseases, today announced progress in its collaboration with Takeda Pharmaceutical Company Limited, originally announced in August. The companies have signed an exclusive license agreement for Takeda’s development, manufacturing and commercialization of NVX‑CoV2373, Novavax’ COVID‑19 vaccine candidate, in Japan.

One of the hallmarks of chronic pain is inflammation, and scientists at the UNC School of Medicine have discovered that anti-inflammatory cells called MRC1+ macrophages are dysfunctional in an animal model of neuropathic pain. Returning these cells to their normal state could offer a route to treating debilitating pain caused by nerve damage or a

26 February 2021 — Positive full results from the pivotal NAVIGATOR Phase III trial showed AstraZeneca and Amgen’s tezepelumab demonstrated a statistically significant and clinically meaningful1 reduction in the annualised asthma exacerbation rate (AAER) in severe, uncontrolled asthma patients.2 The results were presented at the American Academy of Asthma Allergy & Immunology Virtual Annual Meeting.2

The vegan diet is on trend. How this type of diet affects health is the subject of scientific studies. In a new study from the German Federal Institute for Risk Assessment (BfR), the bone health of 36 vegans as well as 36 people following a mixed-food diet was determined with an ultrasound measurement of the

TARRYTOWN, N.Y., Feb. 27, 2021 /PRNewswire/ – Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced detailed results from a Phase 2 proof-of-concept trial evaluating the investigational antibody cocktail REGN1908-1909 in cat-allergic patients with mild asthma. The trial met the primary endpoint of preventing early asthma reactions (EAR, defined as a ≥20% decline in forced expiratory volume over one

Continulus, the Glasgow-headquartered online video-learning platform for health professionals, has secured £0.5m of equity investment from a consortium of UK investors. Image Credit: Continulus The funds will be deployed to strengthen the Continulus management team, as well as enhancing the company’s technological capacity to permit its continuing expansion and collaboration with some of the world’s

KENILWORTH, N.J.–(BUSINESS WIRE) March 1, 2021 — Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced the company is voluntarily withdrawing the U.S. indication for Keytruda (pembrolizumab) for the treatment of patients with metastatic small cell lung cancer (SCLC) with disease progression on or after platinum-based chemotherapy and at least

A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials

BUFFALO, N.Y., March 01, 2021 (GLOBE NEWSWIRE) — Athenex, Inc., (NASDAQ: ATNX), a global biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies for the treatment of cancer and related conditions, today announced that the U.S. Food and Drug Administration (FDA) has issued a complete response letter (CRL) for the company’s New

Lymph nodes in the armpit area can become swollen after a COVID-19 vaccination, and this is a normal reaction that typically goes away with time. Radiologists at Massachusetts General Hospital (MGH) who recently published an approach to managing this situation in women who receive mammograms for breast cancer screening in the American Journal of Roentgenology

PLYMOUTH MEETING, Pa., March 1, 2021 /PRNewswire/ – INOVIO, (NASDAQ:INO), a biotechnology company focused on bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, cancer and HPV-associated diseases, today announced it met primary and secondary endpoints among all evaluable subjects for the REVEAL 1 trial. This trial is one of

We’re re-releasing a story we first reported in 2019, about how insulin got to be so expensive. And this 2021 update includes a check-in with people working to make the potentially lifesaving medicine more available. The story seems especially relevant right now, for two reasons: The rollout of the covid vaccine has reminded all of

INDIANAPOLIS, Feb. 26, 2021 /PRNewswire/ – The U.S. government has agreed to purchase a minimum of 100,000 doses of bamlanivimab (LY-CoV555) 700 mg and etesevimab (LY-CoV016) 1400 mg together, Eli Lilly and Company (NYSE: LLY) announced. Bamlanivimab and etesevimab together recently received emergency use authorization for the treatment of recently diagnosed, mild to moderate COVID-19 in patients who

More than one out of every 10 seniors (10.5%) enrolled in a Medicare Advantage plan, also known as a Medicare managed care option, and living in a rural area, switched to traditional Medicare during 2010-2016. The switch was driven primarily due to low satisfaction with care access, according to a study published this week in

1 March 2021 — AstraZeneca and FibroGen, Inc. (FibroGen) today announced that the US Food and Drug Administration (FDA) informed FibroGen that it will convene a meeting of the Cardiovascular and Renal Drugs Advisory Committee to review the new drug application for roxadustat. Roxadustat is under regulatory review for the treatment of anemia of chronic

Each of the three approved vaccines against coronavirus disease 2019 (COVID-19) – Moderna, BioNTech-Pfizer and Oxford-Astrazeneca – generate forms of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), allowing the immune system to respond with the appropriate antibodies. Since viruses are able to adapt and mutate at high rates, such vaccine cargoes

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the third vaccine for the prevention of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The EUA allows the Janssen COVID-19 Vaccine to be distributed in the U.S for use in individuals 18 years of age

IRS refers to the application of insecticide onto the interior walls of houses. The study, by the Wits Research Institute for Malaria (WRIM) and the London School of Hygiene and Tropical Medicine (LSHTM), was published in The Lancet on 25 February 2021. Targeted vs blanket indoor residual spraying Malaria still represents one of the world’s

The past century or so has seen unprecedented technological, scientific, and sociological evolution worldwide. These have accompanied global shifts in people’s lifestyles and rapid changes in the environment, both natural and man-made. An unfavorable consequence of these alterations has been the increasing burden of cancer on human society. As the country with the largest population,

NEW BRUNSWICK, N.J., February 27, 2021 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced that the U.S. Food and Drug Administration (FDA) has issued Emergency Use Authorization (EUA) for its single-dose COVID-19 vaccine, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson, to prevent COVID-19 in individuals 18 years of age and older. This

A University of Texas at Arlington researcher has received an Office of Naval Research (ONR) grant to examine the mechanics of how blast-like events cause damage to the brain. Ashfaq Adnan, professor of mechanical and aerospace engineering, has received a three-year, $944,845 grant to study the potential link between blast-like trauma and cellular and tissue

More than a month into President Joe Biden’s term, nominees to fill some of the top posts at the Department of Health and Human Services are finally getting confirmation hearings in the Senate, starting with the nominee for secretary, California Attorney General Xavier Becerra. Barring something unexpected, it appears that Becerra, along with the surgeon

NEW BRUNSWICK, N.J., February 26, 2021 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced that the U.S. Food and Drug Administration’s (FDA) Vaccines and Related Biological Products Advisory Committee (VRBPAC) unanimously voted to recommend Emergency Use Authorization (EUA) for the Company’s single-shot COVID-19 vaccine candidate for adults 18 and older, developed by the Janssen Pharmaceutical

Researchers at the Lady Davis Institute (LDI) at the Jewish General Hospital have discovered that increased levels of the protein OAS1 are associated with reduced mortality and less severe disease requiring ventilation among patients with COVID-19. Using drugs that boost OAS1 levels could be explored to try to improve these outcomes. The findings are published

New York, NY and Mainz, Germany, February 17, 2021 — Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced results from an in vitro study that provides additional data on the capability of sera from individuals immunized with the Pfizer-BioNTech COVID-19 vaccine (BNT162b2) to neutralize SARS-CoV-2 with the South African variant spike protein.