Clinical Trials & Research

A new study models an improved bariatric surgery care pathway to estimate the cost-effectiveness of bariatric surgery. For many obese patients, surgery is a key treatment option that can provide long-term health improvement. Evidence over the years has established the positive outcomes of bariatric surgery in suitable patients. Bariatric surgery has been associated with better

Researchers have found evidence that fetal lungs have a microbiome as early as 11 weeks of gestation. Babies are born with a bacterial microbiome already present in the lungs. When, and how, bacteria colonized the lungs was previously unknown. During gestation? Before birth? This led researchers at the University of Alabama to consider the possibility

A comprehensive study of clinical trials on the health benefits of quercetin highlights the effects on blood pressure and cholesterol levels. Quercetin is a plant-derived chemical compound that is found in many fruits, vegetables, and herbs including raspberries, red onions, kale, and fennel. Taking quercetin supplements is thought to improve health due to its anti-inflammatory

Working with a mouse model, researchers have shown relief of endometriosis symptoms using THC as a pain reliever. Pain is complicated.  Many things can cause pain, such as injury, disease, inflammation (swelling), pressure applied to body parts and nerve damage.  There are also many types of medications that attempt to help relieve pain – everything

A new study published in the Journal of Nutrition discovers that walnuts may benefit the gut microbiota and the heart. Our digestive system is colonized by a complex ecosystem of more than 100 trillion microorganisms, both good and bad, commonly referred to as the gut microbiota.  The gut microbiota is critical for digesting food, metabolizing

Recently researchers compared virtual physical therapy after a total knee replacement surgery to traditional in-person physical therapy. Total knee replacement surgeries have doubled in recent years and are not expected to decrease. After surgery, physical therapy is necessary to allow patients to fully recover and use their new knee. However, physical therapy is expensive and

Machine learning is a subset of artificial intelligence, where a computer system performs a specific task by relying on patterns and inferences, rather than a fixed set of instructions. These patterns and inferences are made based on large amounts of data and information that the computer is presented. Therefore, the more data that the computer

Over time, some types of cancers such as melanoma, lung cancer, and kidney cancer present with symptoms of inflammation and immunosuppressed tumour microenvironments (the structural environment around a malignant tumour).An immunosuppressed tumour microenvironment inhibits the activity of the immune system, specifically  T-cells: a key player in the body’s immune response. Immunotherapy is a type of

Researchers from the U.K. have developed new recommendations for complex innovative clinical trials. In a given year, around 18 million people are diagnosed with cancer worldwide and that number is expected to rise to 29.5 million in 2040. Recent discoveries in cancer biology have led to an increase in the development of new cancer therapies.

Recent research shows the potential of certain cancer drugs as a new treatment for chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease (COPD) is characterized by the development of progressive inflammatory lung diseases, which incorporates specific diseases including Chronic bronchitis, emphysema, and refractory asthma (Non-reversible asthma). The disease is characterized by the interference of air

What is it like to spend a night in a sleep lab? How easy is it to sleep hooked up to numerous cables? And is there a link between the microbiome and sleep? Sleep is an essential part of our daily routine and health. Lack of sleep can be detrimental to our well-being. Insomnia is

This study focuses on protecting babies in the neonatal intensive care unit from Staphylococcus aureus. Staphylococcus aureus (S. aureus) is a bacterium that can be found on human skin. Infections with S. aureus can be serious and life-threatening, making it a significant concern in the neonatal intensive care unit (NICU). A recent study investigated whether

Excessively short or long sleep may increase the risk of developing pulmonary fibrosis due to disruptions to the circadian clock. The circadian clock operates as an internal body clock that regulates nearly every cell in the human body. Circadian rhythms drive changes in physiology and behavior along 24-hour cycles, a notable example being the timing

A recent research study provides evidence that apples improve cardiovascular health and reduce cholesterol. A diet rich in plant-based foods such as fruits, vegetables, nuts, seeds, and whole grains is known to reduce the risk of cardiovascular disease, in particular, coronary artery disease and stroke. Apples are the second most-produced fruit in the United States

Patients with non-celiac wheat sensitivity show characteristic miRNA expression patterns that may contribute to the diagnosis of this condition. Wheat is the most widely grown crop in the world. It is consumed in a variety of foods including bread, pasta, noodles, bulgur, and couscous. Gluten is a protein found in wheat, barley, rye, and other

A recent study found that migraine patients have a different response to nitroglycerin compared to non-migraine patients. A migraine is a disorder characterized by recurrent headaches that range from moderate to severe. The physiology behind migraine is complex and the mechanisms are not yet fully understood. Nitroglycerin is a chemical that is used for its

Researchers investigated whether lemborexant for insomnia is effective in promoting and maintaining sleep in older adults. Current therapies for insomnia include cognitive behavioral therapy and medical treatment such as benzodiazepines. However, these treatments are not always effective at promoting and maintaining sleep. A potential treatment for insomnia is a dual orexin receptor antagonist – lemborexant,

A recent study reports promising results for combination tucatinib, trastuzumab, and capecitabine treatment for HER2-positive metastatic breast cancer. HER2 positive breast cancer tends to be more aggressive than other types of breast cancer.  Tucatinib is an oral tyrosine kinase inhibitor that is highly selective for a specific part of the HER2 protein. In a study

As the incidence of diabetes continues to increase globally, the fight against this chronic condition continues. New research explains not only what triggers type 2 diabetes but also how to reverse the condition. The findings also shed light on what leads to remission after reversal for some people. Share on PinterestNew research looks at the

Researchers discover that time of day influences memory recall, mediated by the hippocampal circadian clock in mice. Important mammalian processes such as metabolism, sleep patterns, heart rate, blood pressure, and body temperature are regulated by the body’s internal or 24-hour cycle based circadian clock. In humans, a master biological clock in a tiny region of

A recent study finds that dietary magnesium intake is associated with the risk of both fatal coronary heart disease and sudden cardiac death. Among different age groups, postmenopausal women have the highest prevalence of cardiovascular disease, however, there is currently no clear understanding of the risk factors associated with coronary heart disease and sudden cardiac

Researchers report on the results of a randomized clinical trial of Nilotinib for Parkinson’s disease. Parkinson’s disease is one of the most common neurodegenerative diseases. The disease currently has no cure and symptoms are managed through medication and various forms of therapy. Based on the nature of Parkinson’s disease, researchers have begun to study the

Researchers from the Massachusetts Institute of Technology (MIT), in Cambridge, may have found a combination of drugs that can relieve the pain of passing a kidney stone. They performed their study in pigs. Share on PinterestNew research may help alleviate kidney stone pain. Anyone who has ever passed a kidney stone knows that it can

Researchers discovered a difference in bacteria during times of controlled asthma and severe asthma, leading to a possible link in the composition of the upper airway microbiome and asthma symptoms. Are bacteria to blame for asthma severity? A recent study, published in Nature Communications, suggests that asthma severity in children is linked to the bacteria

A new review strengthens the view that gut bacteria influence the impact of drugs. Your intestines are home to some 35,000 species of bacteria. Among other contributions, these bacteria play an important role in immune system regulation, digestion, and metabolism. It has been known for over 50 years that gut flora impacts the way in

A recent study suggests several strategies to overcome opioid interactions with other drugs in the treatment of chronic pain. A recent study published in The Journal of the American Osteopathic Association describes opioid interactions with other drugs. Commonly prescribed drugs, such as antidepressants, antipsychotics, cardiovascular medications, and many others change the metabolic pathway of opioids in

A recent clinical trial has investigated the safety and effectiveness of Ubrogepant for migraine, with promising results. Migraine is a disorder characterized by frequent headaches typically occurring at one side of the head which can be accompanied by nausea, visual disturbances, and dizziness. A migraine attack can last for hours to days and can interfere

A recent study reports that utilizing Disease-Modifying Therapies (DMT) for MS, healthcare systems can reduce the utilization of resources in the long-term, despite the initially high cost. Multiple Sclerosis is one of the commonest neurological causes of long-term disability. The cause of the disease is unknown, but its symptoms typically involve the optic nerve, brainstem,