Clinical Trials & Research

A new study models an improved bariatric surgery care pathway to estimate the cost-effectiveness of bariatric surgery. For many obese patients, surgery is a key treatment option that can provide long-term health improvement. Evidence over the years has established the positive outcomes of bariatric surgery in suitable patients. Bariatric surgery has been associated with better
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A comprehensive study of clinical trials on the health benefits of quercetin highlights the effects on blood pressure and cholesterol levels. Quercetin is a plant-derived chemical compound that is found in many fruits, vegetables, and herbs including raspberries, red onions, kale, and fennel. Taking quercetin supplements is thought to improve health due to its anti-inflammatory
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Working with a mouse model, researchers have shown relief of endometriosis symptoms using THC as a pain reliever. Pain is complicated.  Many things can cause pain, such as injury, disease, inflammation (swelling), pressure applied to body parts and nerve damage.  There are also many types of medications that attempt to help relieve pain – everything
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Recently researchers compared virtual physical therapy after a total knee replacement surgery to traditional in-person physical therapy. Total knee replacement surgeries have doubled in recent years and are not expected to decrease. After surgery, physical therapy is necessary to allow patients to fully recover and use their new knee. However, physical therapy is expensive and
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Over time, some types of cancers such as melanoma, lung cancer, and kidney cancer present with symptoms of inflammation and immunosuppressed tumour microenvironments (the structural environment around a malignant tumour).An immunosuppressed tumour microenvironment inhibits the activity of the immune system, specifically  T-cells: a key player in the body’s immune response. Immunotherapy is a type of
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Recent research shows the potential of certain cancer drugs as a new treatment for chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease (COPD) is characterized by the development of progressive inflammatory lung diseases, which incorporates specific diseases including Chronic bronchitis, emphysema, and refractory asthma (Non-reversible asthma). The disease is characterized by the interference of air
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A recent study found that migraine patients have a different response to nitroglycerin compared to non-migraine patients. A migraine is a disorder characterized by recurrent headaches that range from moderate to severe. The physiology behind migraine is complex and the mechanisms are not yet fully understood. Nitroglycerin is a chemical that is used for its
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Researchers investigated whether lemborexant for insomnia is effective in promoting and maintaining sleep in older adults. Current therapies for insomnia include cognitive behavioral therapy and medical treatment such as benzodiazepines. However, these treatments are not always effective at promoting and maintaining sleep. A potential treatment for insomnia is a dual orexin receptor antagonist – lemborexant,
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A recent study reports promising results for combination tucatinib, trastuzumab, and capecitabine treatment for HER2-positive metastatic breast cancer. HER2 positive breast cancer tends to be more aggressive than other types of breast cancer.  Tucatinib is an oral tyrosine kinase inhibitor that is highly selective for a specific part of the HER2 protein. In a study
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Researchers discover that time of day influences memory recall, mediated by the hippocampal circadian clock in mice. Important mammalian processes such as metabolism, sleep patterns, heart rate, blood pressure, and body temperature are regulated by the body’s internal or 24-hour cycle based circadian clock. In humans, a master biological clock in a tiny region of
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A recent study finds that dietary magnesium intake is associated with the risk of both fatal coronary heart disease and sudden cardiac death. Among different age groups, postmenopausal women have the highest prevalence of cardiovascular disease, however, there is currently no clear understanding of the risk factors associated with coronary heart disease and sudden cardiac
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Researchers report on the results of a randomized clinical trial of Nilotinib for Parkinson’s disease. Parkinson’s disease is one of the most common neurodegenerative diseases. The disease currently has no cure and symptoms are managed through medication and various forms of therapy. Based on the nature of Parkinson’s disease, researchers have begun to study the
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Researchers discovered a difference in bacteria during times of controlled asthma and severe asthma, leading to a possible link in the composition of the upper airway microbiome and asthma symptoms. Are bacteria to blame for asthma severity? A recent study, published in Nature Communications, suggests that asthma severity in children is linked to the bacteria
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A new review strengthens the view that gut bacteria influence the impact of drugs. Your intestines are home to some 35,000 species of bacteria. Among other contributions, these bacteria play an important role in immune system regulation, digestion, and metabolism. It has been known for over 50 years that gut flora impacts the way in
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A recent study suggests several strategies to overcome opioid interactions with other drugs in the treatment of chronic pain. A recent study published in The Journal of the American Osteopathic Association describes opioid interactions with other drugs. Commonly prescribed drugs, such as antidepressants, antipsychotics, cardiovascular medications, and many others change the metabolic pathway of opioids in
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A recent study reports that utilizing Disease-Modifying Therapies (DMT) for MS, healthcare systems can reduce the utilization of resources in the long-term, despite the initially high cost. Multiple Sclerosis is one of the commonest neurological causes of long-term disability. The cause of the disease is unknown, but its symptoms typically involve the optic nerve, brainstem,
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