Clinical Trials & Research

In a recent study published in Pathology – Research and Practice, researchers evaluated the presence of RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the lung tissue of deceased patients. Study: Cell tropism and viral clearance during SARS-CoV-2 lung infection. Image Credit: CROCOTHERY/Shutterstock SARS-CoV-2 infection results mainly in the mild or asymptomatic course
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Researchers who treated a group of post-surgery bladder cancer patients with the immunotherapy drug atezolizumab have found that patients whose blood contained circulating tumor DNA (ctDNA), responded very well to the treatment. The study is presented today at the European Association of Urology annual congress (EAU22), in Amsterdam. The research was part of a larger
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Data from the world’s largest prostate cancer screening study provides further evidence to support the introduction of a targeted screening program for the disease, say researchers. In 2009, the European Randomised Study of Screening for Prostate Cancer (ERSPC) showed that screening can reduce mortality from prostate cancer by between 20-35 percent. But the earlier and
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Today, CDC continues to lean forward with an aggressive public health response to the monkeypox outbreak by activating its Emergency Operations Center (EOC). This action stands up the CDC’s command center for monitoring and coordinating the emergency response to monkeypox and mobilizing additional CDC personnel and resources. CDC’s activation of the EOC allows the agency
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Brigham and Women’s Hospital announces a $16 million grant from The Leona M. and Harry B. Helmsley Charitable Trust to support the implementation and evaluation of an integrated service delivery model (PEN-Plus) for severe chronic noncommunicable diseases (NCDs) such as type 1 diabetes, rheumatic heart disease, cardiomyopathies, and sickle cell disease in eight low- and
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Both cervical and anal cancer are caused by human papillomavirus. Both diseases also share a common precursor: abnormal cells known as high-grade squamous intraepithelial lesions (HSIL). In cervical neoplasia, treatment of HSILs has been shown to reduce progression to cervical cancer. Recent published research suggests that the same holds true with anal cancer: HSIL treatment
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A team of clinician-scientists and scientists, led by the National Cancer Centre Singapore (NCCS) and A*STAR’s Genome Institute of Singapore (GIS) together with collaborators in Europe and South Korea, used single cell techniques to uncover a central dichotomy for colorectal cancer cells, leading to a proposed update of the classification system for the disease. These
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In a recent study published in the BMJ, researchers investigated the factors that might influence the long-distance (more than two meters) airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in real-world indoor settings, e.g., workplaces and residential apartments. Over a short-range, i.e., under two meters, SARS-CoV-2 transmits via respiratory droplets and aerosols. However,
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A research team at Kyoto University has revealed characteristic behaviors of erythropoietin (Epo)-producing cells. Epo is a hormone produced by the kidney that stimulates red blood cell production. The discovery provides further insight into the mechanism of renal anemia, a common complication of chronic kidney disease—low red blood cell count—which is caused by renal insufficient
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Outsourcing NHS services to the private sector is associated with reduced quality of patient care and increased rates of deaths from treatable causes, according to an analysis published in The Lancet Public Health journal. Findings from the study suggest increased privatization of health services in England between 2013 and 2020 was linked to higher rates
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Young infants are protected against respiratory viruses by passive immunity in human milk, containing antibodies to these viruses because of maternal exposures. The fall in such protection as a result of the widespread social distancing and other non-pharmaceutical interventions implemented during the ongoing coronavirus disease 2019 (COVID-19) pandemic has aroused scientific concern. Study: Decreased Passive Immunity to
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In a recent study posted to the bioRxiv* pre-print server, researchers in the United States described a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibody (mAb) SP1-77 that broadly neutralized its multiple variants of concern (VOCs). Study: Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism. Background Most previously known anti-SARS-CoV-2 antibodies block
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A study of 10,775 high-risk adult patients during the COVID-19 delta variant surge in late 2021 finds that treatment with one of three anti-spike neutralizing monoclonal antibodies for mild to moderate symptoms led to low rates of severe disease, hospitalization, ICU admission and mortality, according to Mayo Clinic researchers. Among patients treated at Mayo Clinic
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In January 2022, the U.S. shifted its guidelines to recommend isolation of five days from COVID-19 symptom onset, followed by an additional five days of mask wearing. However, the progression of the infection as well as the impact of the different variants and vaccinations on when a person is no longer infectious (culture conversion) has
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Canada’s largest dementia research initiative, the Canadian Consortium on Neurodegeneration in Aging (CCNA), has launched an innovative online program that offers older adults the opportunity to increase their knowledge of dementia, improve lifestyle risk factors and engage with researchers. The program, Brain Health PRO (BHPro), offers interactive digital educational modules to empower older adults to
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Tau hyperphosphorylation is the key characteristic pathological hallmarks of Alzheimer’s disease (AD). Recently studies showed periodontitis and periodontal pathogen are significant risk factors for AD. Treponema denticola (T. denticola), as the main periodontal pathogen of periodontitis, has been reported a possible link with AD, however, the role of T. denticola in AD pathogenesis is still
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COVID-19 positive outpatients are at an increased risk of neurodegenerative disorders compared with individuals who tested negative for the virus, a new study presented today at the 8th European Academy of Neurology (EAN) Congress has shown.1 The study, which analysed the health records of over half of the Danish population, found that those who had
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In an article recently published in the journal Viruses, scientists have described the development of a suitable human cell line for high-throughput screening of antiviral drugs targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron
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Colorectal, pancreatic, esophageal and stomach cancers-;some of the deadliest kinds of cancer-; have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment. To combat these treatment-resistant cancers, Thomas University Jefferson researchers led by Adam Snook, PhD, an associate professor of pharmacology and experimental therapeutics, instead use what are, in
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The immune system may play a fundamental role along with the central nervous system in amyotrophic lateral sclerosis (ALS), also known as “Lou Gehrig’s disease,” Mount Sinai researchers report. Their study, published on June 22 in Nature, could have significant implications for diagnosing and treating the devastating neurodegenerative disease. Until now, studies of ALS have
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Probiotics may be a useful tool to help with symptoms of depression, according to a new study.1 A research group from the University of Basel, Switzerland presented an association between certain gut bacteria and decreased depressive symptoms. The article can be found in Nature Translational Psychiatry.   Major depressive disorder treatments need improvement Depression can be
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Porvair Sciences announce eGecko² – an automated barcode application system that provides the ideal high throughput solution for precisely applying barcode labels onto racks of plates and Petri dishes. Image Credit: Porvair Sciences Limited Based upon a robust and proven label printer and print engine, the eGecko² is a completely integrated printer and application unit in
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Some people who experience heart failure have less biodiversity in their gut or have elevated gut metabolites, both of which are associated with more hospital visits and greater risk of death, according to a systematic review of research findings led by Georgetown University School of Nursing & Health Study researchers and colleagues. The gut microbiome
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