Clinical Trials & Research

In a recent study published in the journal Progress in Cardiovascular Diseases, researchers explore whether exercise could be used to treat anxiety. Study: Is exercise a viable therapy for anxiety? Systematic review of recent literature and critical analysis. Image Credit: GP PIXSTOCK / Shutterstock.com The mental health benefits of exercise Lifestyle psychiatry acknowledges the impact of various health

Researchers have for the first time characterized a unique molecular mechanism of the early stages of programmed cell death or apoptosis, a process which plays a crucial role in prevention of cancer. The study, which is published today (Friday 2nd June 2023) in Science Advances, was led by Dr Luke Clifton at the STFC ISIS

Beneath and beyond the reddish, flaky lesions that form in the skin of those with psoriasis, mild and severe forms of the disease can be told apart by the activity of key cells and signaling pathways, a new study shows. Led by researchers at NYU Grossman School of Medicine, the study mapped hidden features of

JERSEY CITY, N.J., June 2, 2023. MEDSIR announced today the positive results of the PHERGain trial. This study is the first to use an adaptive design that tailors treatment in the neoadjuvant/adjuvant setting of patients with HER2-positive early breast cancer. The main objective of this trial was to assess the feasibility of a chemotherapy-free strategy

Our skin contains specialized long-lived killer cells that protect against intruders. Researchers at Karolinska Institutet in Sweden and the University of Copenhagen in Denmark have now identified how these cells are formed, and shown that high levels of memory killer cells in cancer tissue correlate with a better survival rate in people with melanoma. The

There’s one question that Hollings Cancer Center researcher Jennifer Dahne, Ph.D., co-director of the remote and virtual trials program at the South Carolina Clinical & Translational Research Institute, hears more than any other as she consults with clinical researchers about how to set up remote trials, also known as decentralized trials. Will these trials overcome

CAMBRIDGE, Mass., June 1, 2023. TriNetX, the global network of healthcare organizations driving real-world research to accelerate the development of new therapies, enabled researchers at Hospital Quirónsalud Marbella and Hospital Campo de Gibraltar to leverage European and global real-world data (RWD) for a study that found patients diagnosed with sleep apnea have a lower risk

While ingestible video capsule endoscopes have been around for many years, the capsules have been limited by the fact that they could not be controlled by physicians. They moved passively, driven only by gravity and the natural movement of the body. Now, according to a first-of-its-kind research study at George Washington University, physicians can remotely

Although cerebral palsy (CP) is the most common childhood-onset disability, there are very few evidence-based clinical practice guidelines or recommendations on how to treat and manage this condition. A special issue of the Journal of Pediatric Rehabilitation Medicine, guest-edited by Rachel Byrne, Deborah Gaebler-Spira, Michael Green, and Heakyung Kim, in partnership with the Cerebral Palsy

May 31, 2023 — Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment. Scientists discovered that people with the disorder have an overactive version of a protein called STAT4, which

Newborn babies who experience low levels of oxygen in their body tissues (hypoxia) due to sleep apnea, for example, tend to develop respiratory problems and hypertension (high blood pressure) in adulthood, and these problems may persist for the rest of their lives. Research by scientists at São Paulo State University (UNESP) in Brazil shows for

MORRISVILLE, N.C., May 30, 2023. Immorna, a rapidly expanding biotechnology company focusing on the development of multi-platform RNA-based therapeutics and vaccines, today announced that the first subject has been dosed in the Company’s First-In-Human (FIH) Phase 1 multi-center study of JCXH-105, a self-replicating RNA (srRNA) vaccine being developed for the prevention of Shingles (Herpes Zoster;

In a recent study published in the journal Nature Communications, researchers examined the phenotypic and genetic evolution of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses following their spread to North America (NAm). Clade 2.3.4.4b A(H5N1) viruses spread rapidly over Africa, Europe, and Asia in 2021, infecting domestic animals and wild birds. Viruses of the

Study demonstrates statistically significant and clinically relevant reduction in annualized bleeding rate compared to prophylaxis and on-demand intravenous regimens Marstacimab, if approved, has the potential to become the first once-weekly subcutaneous treatment for people living with hemophilia B and the first treatment administered as a flat dose for people living with hemophilia A or B

Researchers at Indiana University School of Medicine have discovered alternative gene splicing, which occurs during gene expression, can impact a person’s risk of alcohol use disorder (AUD). They recently published their findings in Molecular Psychiatry. AUD is a common and complex genetic disorder that happens people experience problems related to excessive alcohol consumption. This discovery

HAMILTON, BERMUDA / ACCESSWIRE / May 24, 2023 / Altamira Therapeutics Ltd. (Nasdaq:CYTO), a company dedicated to developing therapeutics that address important unmet medical needs, today announced positive and statistically significant top-line results from the randomized controlled NASAR clinical trial evaluating its Bentrio nasal spray in patients with seasonal allergic rhinitis (SAR). Bentrio nasal spray

A new study has shown that humans may have evolved a spring-like arch to help us walk on two feet. Researchers studying the evolution of bipedal walking have long assumed that the raised arch of the foot helps us walk by acting as a lever which propels the body forward. But a global team of

MELBOURNE, Australia, May 29, 2023. Amplia Therapeutics Limited (“Amplia” or the “Company”) is pleased to announce new data showing the efficacy of its investigational FAK inhibitor, AMP945, in a preclinical model of pancreatic cancer, when used in combination with FOLFIRINOX treatment. FOLFIRINOX, a combination of four chemotherapies used in the treatment of pancreatic cancer patients,

Could a personalized vaccine be the answer to skin cancer? Breakthrough research could mean personalized cancer vaccines become a reality. Melanoma, an aggressive type of skin cancer, arises from the continuous growth of pigment-producing skin cells. With stage IV having a five-year survival rate of 16.2%, effective treatments are needed promptly.   Conventional treatment supplemented with

Research led by the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre (BRC) and Universite Paris Cite, and supported by worldwide partners in Canada, the USA and Australia, has identified new genes that are associated with an increased risk of a type of heart attack primarily affecting young to middle-aged women.

TARRYTOWN, N.Y., May 25, 2023 (GLOBE NEWSWIRE) — Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced positive data from three independent cohorts evaluating an investigational combination of LAG-3 inhibitor fianlimab and PD-1 inhibitor Libtayo® (cemiplimab) in adults with advanced melanoma. The early clinical trial results, which demonstrated the combination led to clinically meaningful and durable results

For the parents of children who stutter, managing the communication disorder alone can be stressful and isolating. At Saint Louis University’s Speech-Language and Hearing Clinic, one mother discovered a team to help her daughter communicate more confidently at school and home.  Now, Jaimie Saunders, the mother of a child who stutters, is on a mission

TARRYTOWN, N.Y., May 25, 2023 (GLOBE NEWSWIRE) — Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced updated data from two Phase 2 expansion dose cohorts evaluating investigational linvoseltamab (formerly REGN5458) in patients with heavily pre-treated, relapsed/refractory (R/R) multiple myeloma. The results will be shared in an oral session at the 2023 American Society of Clinical Oncology

On the sidelines of the 76th World Health Assembly, Harvard University’s Professor of Global Health Systems, Rifat Atun, the Copenhagen Institute for Future Studies (CIFS), Microsoft, Roche, and Siemens Healthineers came together to announce the formation of the Movement Health Foundation. While many countries around the world are facing enormous pressures on their healthcare systems,

Over 37 million Americans have diabetes, and 90-95% of that population are diagnosed with type 2 diabetes. Lifestyle interventions, such as a healthy diet and a regular physical activity program, are methods to manage diabetes. A new study from a collaboration of investigators at Brigham and Women’s Hospital, a founding member of the Mass General

1. Use hot water bottles to lower your core temperature Using a hot water bottle might sound like a strange way to combat heat, but James the sleep geek recommends raising your core temperature slightly by placing a luke-warm hot water bottle on your feet thirty minutes before bed; that way, when you go to

ONWARD Medical N.V. (Euronext: ONWD), the medical technology company creating innovative spinal cord stimulation therapies to restore movement, function, and independence in people with spinal cord injury (SCI), today announces a publication in Nature showing that a wireless brain-computer interface (BCI) can use thought to modulate ARC Therapy. Researchers reported that when paired with ARC

PHILADELPHIA, May 26, 2023. IgA deficiency is the most common primary immune deficiency worldwide, but its presentation has puzzled physcians and researchers. Some with the disorder present with symptoms like recurrent infections, autoimmune disease, or allergies, whereas others have no symptoms at all and only become aware of their IgA-deficient status through an incidental finding