EEG study identifies neural signal that may explain the variation of autism spectrum disorder

Children

An electroencephalogram (EEG) study of adolescents with autism spectrum disorder (ASD) identified a neural signal that may help explain the variation of how those with ASD perceive or understand the mental states of others (called “Theory of Mind”). Led by Matthew Lerner, PhD, of Stony Brook University, the study is published in Clinical Psychological Science.

While challenges with Theory of Mind have long been associated with ASD, it is now known that many people with ASD do not struggle with his sort of perspective-taking. For example, those with increased autism symptoms do not necessarily exhibit increased deficits in the understanding others socially, and vice versa. However, this variability in Theory of Mind is not well understood.

A total of 78 adolescents ages 11 to 17 participated in the study, most with ASD. With the EEG in place, the participants viewed Theory of Mind vignettes of social scenes and made mental state inferences on the characters’ behavior as their brain activity was recorded.

While we know the brains of those with ASD process social experiences differently, little work has linked these differences directly to Theory of Mind. In our study, we first identified an electrical brain-based marker that relates to Theory of Mind ability in typically-developing teens, and found that it does so in ASD, too. This marker, called the Late Positive Complex (LPC), seems to reflect one’s ability to hold and reflect an idea or situation in one’s mind.”

Matthew Lerner, Associate Professor of Psychology, Psychiatry and Pediatrics, Department of Psychology, Stony Brook University

Lerner and his team found that LPC scores in ASD adolescents related to better Theory of Mind accuracy and fewer ASD symptoms. More importantly, The LPC statistically explained the relationship between ASD symptoms and Theory of Mind accuracy, suggesting that this EEG signal may explain why some individuals with ASD struggle with Theory of Mind.

“Essentially, if this marker is present in someone with ASD, they do not seem to have trouble with Theory of Mind, but if it is absent they do.”

The authors point out that evidence from the EEG study suggests that deficits in Theory of Mind reasoning in those with ASD occur relatively early in the brain process of perception, and stem from difficulties holding an idea or image in mind when it is no longer visible.

They conclude that “the current findings increase understanding of the neural mechanisms implicated in social-cognitive functioning in ASD and further inform clinical practice, research and theory involving social cognition in ASD.”

Journal reference:

Libsack, E. J., et al. (2021) An Electrocortical Measure Associated With Metarepresentation Mediates the Relationship Between Autism Symptoms and Theory of Mind. Clinical Psychological Science. doi.org/10.1177/21677026211021975.

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