New method to measure drugs and lipids in cells could lead to effective treatments for diseases

Clinical Trials & Research

A new state-of-the-art method that measures the amounts of drugs and lipids (fats) in individual cells could help health professionals target more effective treatments for diseases such as tuberculosis (TB).

Researchers from the University of Surrey were able to isolate individual living cells that contained drugs commonly used to treat TB and found that each cell absorbed the drug differently, and each cell had a unique lipid “fingerprint”.

There was a big variation in how much drug was found in each cell – this indicates that different cells absorb drugs differently. This could prove significant to improving our understanding of life-saving treatments – not only for TB but for other infectious diseases and cancer too.”

Dr Holly-May Lewis, first author of the study, University of Surrey

In the study, the Surrey researchers demonstrated the use of a technique called nanocapillary sampling, where scientists use a microscopic tool to trap individual cells. The researchers then used another technique, liquid chromatography, to precisely measure the levels of drugs and lipids.

Professor Melanie Bailey, corresponding author of the study from the University of Surrey, said:

“Surrey is one of the few places in the country where it’s possible to experiment with these cutting-edge measuring techniques. We recently secured funding to establish a national research facility that will help researchers from the UK to make single cell measurements. If we are ever able to develop effective therapeutic methods to treat devastating diseases or fight the pandemics of the future, more out-of-box scientific thinking like this is needed.”

The research has been published in the journal Analyst.

Journal reference:

Lewis, H-M., et al. (2023) Nanocapillary sampling coupled to liquid chromatography mass spectrometry delivers single cell drug measurement and lipid fingerprints. Analyst.

Articles You May Like

Substance use disorders not associated with COVID-19-related mortality
Maternal weight gain in pregnancy linked to children’s risk of neurodevelopmental disorders
Brain Stimulation Can Improve Prognosis Following a Stroke
Shedding Weight May Benefit Your Heart, Reduces Diabetes Risk Even If You Regain Some
NIH Researchers Discover New Autoinflammatory Disease, Suggest Target for Potential Treatments

Leave a Reply

Your email address will not be published. Required fields are marked *