New Alzheimer’s Trial Data; Microbiome and MS; Monkeypox’s Neuro Complications

News

The oral beta-amyloid blocker ALZ-801 (valiltramiprosate) reduced plasma phosphorylated tau (p-tau181) by 41% and preserved hippocampal volume in a phase II study of Alzheimer’s patients with an APOE4 allele, Alzheon announced.

Investigational crenezumab did not reduce clinical decline or change disease-relevant biomarkers in two phase III trials of people with early Alzheimer’s. (JAMA Neurology)

With recent developments in Alzheimer’s research, scientists at drug firms around the world are optimistic for a breakthrough. (The Sunday Times)

Six metabolites, including four that were sugar-related, were associated with lower global cognitive function in people of diverse races and ethnicities. (Alzheimer’s & Dementia)

The gut microbiome was linked with multiple sclerosis (MS) risk and disease course. (Cell)

A second expanded-access patient with secondary progressive MS showed continued clinical improvements after 6 months of treatment with intranasal foralumab, Tiziana Life Sciences said.

Combining a seed amplification assay with an enzyme-linked immunosorbent assay (ELISA) for alpha-synuclein aggregates provided better information about Parkinson’s disease severity. (Neurology)

A single infusion of adjunctive rituximab led to better 4-month outcomes in new-onset generalized myasthenia gravis, the RINOMAX trial showed. (JAMA Neurology)

A molecular circadian clock may help brains recover after injury. (eNeuro)

Headaches, mood disturbances, and rare presentations of encephalitis, transverse myelitis, and seizures have been associated with monkeypox virus. (JAMA Neurology)

Healthy lifestyle factors were linked with a significantly lower risk of dementia in people with type 2 diabetes. (Neurology)

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

Articles You May Like

Viruses exploit ability to sense the environment to maximize their infective yield
Financial wellbeing: The crucial link with mental health and the role of employers in tackling the cost of living crisis
Biogen to pay $900 million to settle allegations it paid doctors kickbacks to prescribe multiple sclerosis drugs
Dietary sugar may disrupt gut microbiota and induce metabolic complications
‘Sit Down, Shut Up and Sign, Don’t Make Waves’: What We Heard This Week

Leave a Reply

Your email address will not be published.