COVID-19

Most severe acute respiratory syndrome coronavirus (SARS-CoV-2) mutations cause only mild harm. However, a small percentage of mutations can boost viral virulence and promote host-virus interactions that are critical to viral entry and infection. For example, SARS-CoV-2 spike protein mutations can significantly affect viral behavior, as the spike protein mediates viral attachment to host cell
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A monoclonal antibody Covid treatment from Vir Biotechnology and GlaxoSmithKline “stands up well” to all variants of the virus, Vir President and CEO George Scangos told CNBC’s “Power Lunch” on Wednesday. Scangos’ comments came after the two companies announced contracts to sell $1 billion worth of their antibody, sotrovimab, to the U.S. government. The Food
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The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells by binding its spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor of the host. The SARS-CoV-2 spike protein is a trimer of S1/S2 heterodimers with 2 ACE2 receptor binding domains (RBD) attached via a hinge region, allowing conformational flexibility. Neutralizing antibodies
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A surprising new study published on the preprint server medRxiv* finds that following mild coronavirus disease 2019 (COVID-19), children are significantly more likely to remain seronegative than adults, irrespective of the viral load or symptom severity. This finding has implications for the serological diagnosis of COVID-19 in children, as well as for their immunity following
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The coronavirus disease 2019 (COVID-19) pandemic, caused by the β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), alerted the world to the seriousness of the threat posed by novel viruses. To protect the world’s population from similar future outbreaks, broadly protective vaccines against SARS-related coronaviruses are urgently needed. In a recent study published in Journal
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A masking mandate in North Carolina schools during the early weeks of the Delta variant surge resulted in a lower rate of infection among school children and staff members than what was reported in the broader community, according to a new report from the ABC Science Collaborative. Publishing in the journal Pediatrics, the analysis includes
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Maryland National Guard Specialist James Truong (L) administers a Moderna coronavirus vaccine at CASA de Maryland’s Wheaton Welcome Center on May 21, 2021 in Wheaton, Maryland. Chip Somodevilla | Getty Images Food and Drug Administration scientists on Tuesday declined to take a stance on whether to back booster shots of Moderna’s Covid-19 vaccine, saying data
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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. High-efficiency particulate air (HEPA) filters and ultraviolet (UV) light sterilization effectively remove SARS-CoV-2 particles from the air — the first such evidence in a real-world test, researchers report in the preprint server medRxiv. The journal Nature reported this week that the
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In this article PFE Safeway pharmacist Ashley McGee fills a syringe with the Pfizer COVID-19 booster vaccination at a vaccination booster shot clinic on October 01, 2021 in San Rafael, California. Justin Sullivan | Getty Images The effectiveness of Pfizer and BioNTech‘s Covid-19 vaccine against infection tumbles over several months, falling from a peak of
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A monoclonal antibody cocktail designed for COVID-19 pre-exposure prophylaxis was safe, and appeared to be effective across populations at risk of severe COVID and who may have a subpar response to vaccination, a researcher said. AZD7442 (tixagevimab/cilgavimab) met its primary endpoint, reducing the risk of symptomatic COVID-19 among high-risk populations by 77% (95% CI 46%-90%),
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Researchers have warned that the United States has not yet reached the necessary thresholds for achieving population immunity against severe acute respiratory coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). The team – from RTI International in Research Triangle Park, North Carolina, and Pfizer Inc. in Collegeville, Pennsylvania – says that
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A concerning and dangerous trend is circulating on social media channels like Facebook, Twitter, and TikTok. People are breathing in hydrogen peroxide through nebulizers to try to prevent or treat COVID-19. DO NOT put hydrogen peroxide into your nebulizer and breathe it in. This is dangerous! It is not a way to prevent nor treat
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World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus attends a news conference in Geneva Switzerland July 3, 2020. Fabrice Coffrini | Reuters World Health Organization officials repeated their protests Tuesday against Covid-19 booster shots for the general public, even as the U.S. readies this week to authorize their distribution across a wide swath of America.
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Researchers in the UK have conducted a study suggesting that severe disease in children and young people admitted to hospital following infection with severe acute respiratory syndrome coronavirus (SARS-CoV-2) is still rare and was no more common during the second wave of infections than the first. The SARS-CoV-2 virus is the agent responsible for the
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Researchers in the United States have conducted a study showing that the antibody response to vaccination designed to protect against coronavirus disease 2019 (COVID-19) wanes substantially over time among patients receiving maintenance dialysis. The team’s study of more than 1,500 individuals found that antibody titers against the COVID-19 causative agent – severe acute respiratory syndrome
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Both biologics and mesalamine/sulfasalazine were not linked to severe COVID-19 outcomes in inflammatory bowel disease (IBD) patients, according to findings from the ongoing global SECURE-IBD trial. There was no association between mesalamine/sulfasalazine and adverse COVID outcomes. And when examining biologic-treated patients, there was no link between mesalamine/sulfasalazine use and either severe COVID-19 (adjusted odds ratio
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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. COVID-19 has now killed at least 675,000 Americans, a death toll that has surpassed the estimates of the number of Americans who died during the 1918 influenza pandemic, according to data collected by Johns Hopkins University. Although the raw numbers match,
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Adhering to a diet and exercise program to manage health can be a challenge for anyone. But maintaining a healthy weight may present unique challenges for young adults with inherent barriers such as cognitive impairment. A pilot study at the University of Cincinnati found that young adults with autism spectrum disorder (ASD) and intellectual disabilities
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It seems these days there’s a questionnaire for everything. In place of our old Review of Systems (or perhaps in addition to), there are now multiple screening questionnaires and symptom-based tools that patients can fill out in advance of their office visits. For a while there, our electronic medical record was sending out a complete
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The delta variant of the novel coronavirus has brought forth massive spikes in COVID-19 transmissions in the country and across the globe. And though children are also seeing a surge in cases, there is no cause for alarm among the younger population.  COVID-19 In Kids In the U.S., transmissions involving children under 12 have soared
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Allergic reactions to the new mRNA-based COVID-19 vaccines are rare, typically mild and treatable, and they should not deter people from becoming vaccinated, according to research from the Stanford University School of Medicine. The findings will be published online Sept. 17 in JAMA Network Open. We wanted to understand the spectrum of allergies to the
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The intelligent fabric of these masks has been created by a team of researchers from the San Alberto Magno Traslational Centre (CITSAM-UCV), led by professor Ángel Serrano. The Catholic University of Valencia and Valencian company Visor Medical, manufacturer of preventive health technology for innovation, have released a type IIR surgical mask with an intelligent fabric
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People wearing face masks as a preventive measure against the spread of Covid-19 in Singapore. Maverick Asio | SOPA Images | LightRocket | Getty Images SINGAPORE — Singapore reported more than 1,000 Covid cases for two straight days over the weekend —the first time infections breached that level since April 2020, at the height of
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While poor sleep was linked to higher levels of stress during the COVID-19 pandemic, more teens actually obtained the recommended amount of sleep compared to pre-pandemic sleep patterns, according to a new study from McGill University. Changes to daily routines triggered by lockdowns allowed teenagers to follow their biological impulse to wake up and sleep
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