SARS-CoV-2

Most severe acute respiratory syndrome coronavirus (SARS-CoV-2) mutations cause only mild harm. However, a small percentage of mutations can boost viral virulence and promote host-virus interactions that are critical to viral entry and infection. For example, SARS-CoV-2 spike protein mutations can significantly affect viral behavior, as the spike protein mediates viral attachment to host cell
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The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells by binding its spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor of the host. The SARS-CoV-2 spike protein is a trimer of S1/S2 heterodimers with 2 ACE2 receptor binding domains (RBD) attached via a hinge region, allowing conformational flexibility. Neutralizing antibodies
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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. High-efficiency particulate air (HEPA) filters and ultraviolet (UV) light sterilization effectively remove SARS-CoV-2 particles from the air — the first such evidence in a real-world test, researchers report in the preprint server medRxiv. The journal Nature reported this week that the
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Outbreaks of infectious diseases have been recorded throughout history. Currently, SARS-CoV-2, a contagious virus that causes the disease called COVID-19, is impacting individuals worldwide. Many countries have set their sight on an effective vaccination program to end their infectious disease outbreaks. The term “herd immunity” has been mentioned in association with ending the COVID-19 outbreaks.
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Now that the first COVID-19 vaccines are being rolled out, Operation Warp Speed, the FDA, and the CDC have recommended that governors proceed first with vaccinating two groups: healthcare workers and residents in nursing homes. But what about after that? Planning has started in all the states and territories regarding who will get the vaccine
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In the ongoing coronavirus disease 2019 (COVID-19) pandemic, much research has focused on the role of neutralizing antibodies in countering infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Most of these studies have been based on genome sequencing, showing matches between the Hypervariable Region (HVR) and the antigen’s receptor-binding domain (RBD). The results have
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Early on in the ongoing coronavirus disease 2019 (COVID-19) pandemic, the antibiotic azithromycin was regarded as being a potentially highly effective drug against the virus that causes it, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hundreds of thousands of doses have been dispensed on this basis to treat these patients. Evidence in support of this
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